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A Microplate Assay to Assess Chemical Effects on RBL-2H3 Mast Cell Degranulation: Effects of Triclosan without Use of an Organic Solvent
Published on: November 1, 2013
Effect of triclosan on the pathogenesis of allergic diseases among children
Min-Hua Lin1,2, She-Yu Chiu3, Wen-Chao Ho4,5
1Department of Nutrition, China Medical University, No.100, Sec.1, Jingmao Road, Beitun Dist, Taichung, 4046040, Taiwan.
Insights
Triclosan (TCS) exposure in children is linked to higher IgE levels and increased risks of asthma and atopic dermatitis. These associations were particularly notable in boys, highlighting potential environmental health concerns.
Area of Science:
- Environmental Health
- Pediatric Allergy
- Toxicology
Background:
- Limited research exists on antibacterial agents and allergic diseases in Taiwanese children.
- Antibacterial agents like triclosan (TCS) are common, raising concerns about potential health effects.
Purpose of the Study:
- To investigate the association between triclosan (TCS) exposure and allergic diseases in preschoolers.
- To examine the relationship between TCS exposure, disease-specific IgE titers, and child's sex.
Main Methods:
- Utilized data from the Childhood Environment and Allergic Diseases Study (CEAS) cohort.
- Analyzed urine and blood samples for TCS and IgE concentrations at ages 3 and 6.
- Evaluated correlations between TCS levels and IgE, as well as allergic diseases.
Main Results:
- TCS levels decreased from age 3 to 6 but remained positively correlated with serum IgE.
- Significant associations were found between TCS exposure and asthma and atopic dermatitis.
- Boys showed stronger correlations between TCS and IgE, and associations with asthma, allergic rhinitis, and atopic dermatitis.
Conclusions:
- Triclosan (TCS) exposure is associated with elevated IgE levels in children.
- TCS exposure may increase the risk of developing pediatric atopic disorders, including asthma and dermatitis.
Background:
Few studies have assessed associations between allergic diseases and antibacterial agents in Taiwanese children.
Objective:
This study aimed to investigate the association of triclosan (TCS) exposure with allergic diseases among preschoolers, disease-specific IgE titers, and a child's sex.
Methods:
Pediatric data were obtained from the Childhood Environment and Allergic Diseases Study (CEAS; 2010) cohort, and their urine and blood samples were used to analyze TCS and IgE concentrations (age 3 group). Three years later, clinical data were obtained again from the age 3 group (age 6 group). Correlations of TCS levels at ages 3 and 6 years with IgE levels and allergic diseases were evaluated.
Results:
The TCS levels were higher at age 3 than at age 6 (geometric mean, 1.05 ng/ml vs 0.37 ng/ml). TCS levels were positively correlated with serum IgE levels at ages 3 and 6 years. Asthma and atopic dermatitis were significantly associated with TCS (adjusted OR 1.14, 95% confidence interval [CI] 1.01-1.29; OR 1.22, 95% CI 1.05-1.41). Sex-stratified analysis revealed that TCS levels were positively correlated with IgE levels among boys in the age 6 group and significantly associated with asthma, allergic rhinitis, and atopic dermatitis among boys.
Significance:
TCS exposure is associated with IgE levels and a potentially high risk of pediatric atopic disorders.
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