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Updated: Nov 15, 2025

Transplantation of Bioengineered Lung Using Decellularized Mouse Lungs and Primary Human Endothelial Cells
Published on: March 28, 2025
ProtekDuo as a bridge to lung transplant and heart-lung transplant
Neeraj Sinha1, Ahmad Goodarzi2, Radhika Akku3
1Division of Pulmonary and Critical Care Medicine, Transplant Pulmonology, Miami Transplant Institute, University of Miami, Miami, FL, USA.
Abstract:
Recent advances in technology have led to significantly greater use of extracorporeal membrane oxygenation (ECMO) as a bridge to lung transplantation with better outcomes. The novel ProtekDuo veno-venous ECMO (CardiacAssist, Inc.) has gained significance as it facilitates effective decompression of the right heart in patients with acute decompensation, while also providing consistent and effective gas exchange by eliminating recirculation. Here, we report two cases of effectively using ProtekDuo veno-venous ECMO: one case as a bridge to lung transplantation and another case as a bridge to heart-lung transplantation.

