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Stress-induced occupancy and translocation of hippocampal glucocorticoid receptors
M J Meaney1, V Viau, D H Aitken
1Douglas Hospital Research Centre, Department of Psychiatry, Faculty of Medicine, McGill University, Canada.
Brain Research
|March 29, 1988
Abstract:
Using an exchange assay for glucocorticoid receptors, we found that immobilization stress resulted in a approximately 50% translocation of receptors (i.e. receptors assumed to be chromatin bound) from soluble fractions prepared from hippocampal tissue. The increased hormone-receptor signal persisted for about 2-4 h following the termination of the stressor. This time course is consistent with the known temporal pattern for the negative feedback of glucocorticoids on adrenocortical activity.