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Updated: Nov 15, 2025

Interventional Diagnostic Procedure: A Practical Guide for the Assessment of Coronary Vascular Function
Published on: March 15, 2022
Physiologic Assessment after Coronary Stent Implantation
Doyeon Hwang1, Seokhun Yang1, Jinlong Zhang2
1Department of Internal Medicine and Cardiovascular Center, Seoul National University Hospital, Seoul, Korea.
Insights
Post-procedure physiologic assessment is crucial after coronary revascularization to confirm ischemia relief. This ensures percutaneous coronary intervention (PCI) effectiveness and guides further treatment for better patient outcomes.
Area of Science:
- Cardiology
- Interventional Cardiology
- Physiology
Background:
- Myocardial ischemia must be present for coronary revascularization to be beneficial.
- Physiology-guided revascularization, using fractional flow reserve and non-hyperemic pressure ratios, has demonstrated benefits.
- Residual ischemia can persist in 15-20% of cases even after angiographically successful percutaneous coronary intervention (PCI).
Purpose of the Study:
- To review the current evidence supporting post-PCI physiologic assessment.
- To guide the interpretation of post-PCI physiologic findings.
- To explore future directions in post-PCI physiologic assessment.
Main Methods:
- Review of recent randomized studies and clinical evidence.
- Analysis of diagnostic tools like fractional flow reserve and non-hyperemic pressure ratios.
- Discussion of interpretation criteria for post-PCI hemodynamic measurements.
Main Results:
- Physiology-guided revascularization does not always eliminate ischemia.
- Post-PCI assessment is vital for evaluating PCI appropriateness and identifying lesions needing further intervention.
- It aids in risk stratification after percutaneous coronary intervention.
Conclusions:
- Post-PCI physiologic assessment is essential for confirming procedural success and optimizing patient care.
- It helps in identifying residual ischemia and guiding subsequent treatment decisions.
- Further research into post-PCI assessment techniques is warranted.
Abstract:
The presence of myocardial ischemia is a prerequisite for the benefit of coronary revascularization. In the cardiac catheterization laboratory, fractional flow reserve and non-hyperemic pressure ratios are used to define the ischemia-causing coronary stenosis, and several randomized studies showed the benefit of physiology-guided coronary revascularization. However, physiology-guided revascularization does not necessarily guarantee the relief of ischemia. Recent studies reported that residual ischemia might exist in up to 15-20% of cases after angiographically successful percutaneous coronary intervention (PCI). Therefore, post-PCI physiologic assessment is necessary for judging the appropriateness of PCI, detecting the lesions that may benefit from additional PCI, and risk stratification after PCI. This review will focus on the current evidence for post-PCI physiologic assessment, how to interpret these findings, and the future perspectives of physiologic assessment after PCI.
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