Light-emitting diode stimulates radiodermatitis recovery
Cristina Pires Camargo1, Heloisa Andrade Carvalho2, Feres Camargo Maluf3
1MD, PhD. Universidade de São Paulo - Medical School - Laboratory of Microsurgery and Plastic Surgery - São Paulo (SP), Brazil.
Purpose:
To evaluate the effect of light-emitting diode (LED) in an experimental model of radiodermatitis.
Methods:
Ten male Wistar rats weighing 200-250 g were analyzed. Radiation was delivered in a single dose (20 Gy with Strontium-90 dermatological plaques), two areas per animal. After 15 days, they were divided into two groups: control group (n = 5) and LED group (n = 5), which was treated during 21 days later (LED 660 nm, 10 min in alternate days). The endpoints were radiodermatitis scale, histological analysis HE, Picrius Sirius and the gene expression of interleukin-10 (IL-10) and matrix metalloproteinase-9 (MMP-9).
Results:
The LED group showed a higher number of dermal appendages (p = 0.04) and angiogenesis(p = 0.007), a tendency towards higher IL-10 (p = 0.06) and an increase in MMP-9 (p = 0.004) when compared to the control group.
Conclusions:
This study suggested that the use of LED for radiodermatitis increased skin regeneration.
