Heteroditopic Calix[6]arene Based Intervowen and Interlocked Molecular Devices

Area of Science:

• Supramolecular Chemistry
• Organic Synthesis
• Macrocyclic Chemistry

Background:

• Calixarenes are established supramolecular platforms for molecular recognition.
• Larger calixarenes, like calix[6]arene, offer potential for binding larger guests but face synthetic challenges.
• Conformational flexibility and regioselective functionalization hinder the use of larger calixarenes.

Purpose of the Study:

• To review advancements in using calix[6]arene as a platform for synthesizing oriented (pseudo)rotaxanes.
• To explore the influence of calix[6]arene hosts on the properties of bound guests.
• To highlight the utility of larger calixarene macrocycles in supramolecular chemistry.

Main Methods:

• Regio- and stereocontrolled functionalization of calix[6]arene.
• Synthesis of oriented (pseudo)rotaxanes utilizing calix[6]arene as a macrocyclic wheel.
• Investigation of host-guest interactions and their effects on guest reactivity and spectroscopy.

Main Results:

• Demonstrated successful synthesis of complex structures using calix[6]arene.
• Showcased the ability of calix[6]arene to act as a macrocyclic component in rotaxane synthesis.
• Documented modulation of guest properties upon complexation with calix[6]arene.

Conclusions:

• Calix[6]arene has emerged as a valuable platform for advanced supramolecular architectures.
• Synthetic methodologies have been developed to overcome previous limitations in utilizing larger calixarenes.
• Calix[6]arene-based systems offer tunable platforms for controlling guest behavior and properties.