Related Experiment Video
Updated: Jul 25, 2026
A Preclinical Model of Orthotopic Heart Transplantation in Bama Miniature Pigs Using Biatrial Technique
Published on: June 13, 2025
Midterm Prognosis of Sexagenary Patients after Transcatheter Device Closure of Atrial Septal Defects: a
Kai-Peng Sun1,2,3, Ning Xu1,2,3, Shu-Ting Huang1,2,3
1Department of Cardiac Surgery, Fujian Maternity and Child Health Hospital, Affiliated Hospital of Fujian Medical University, Fuzhou, People's Republic of China.
Insights
Transcatheter device closure effectively treats atrial septal defects (ASDs) in sexagenary patients, significantly improving symptoms and quality of life. This minimally invasive procedure offers a favorable midterm prognosis for older adults with ASDs.
Area of Science:
- Cardiology
- Interventional Cardiology
- Geriatric Medicine
Background:
- Atrial septal defects (ASDs) can impact the health and quality of life of older adults.
- Transcatheter device closure offers a less invasive alternative to surgical repair for ASDs.
Purpose of the Study:
- To evaluate the efficacy and midterm prognosis of transcatheter device closure for ASDs in sexagenary (60-69 years old) patients in China.
- To assess the impact of ASD closure on clinical symptoms, echocardiographic parameters, and quality of life.
Main Methods:
- A prospective study included 46 sexagenary patients undergoing transcatheter ASD closure.
- Preoperative and postoperative data on clinical symptoms, echocardiography, and quality of life (SF-36) were collected and analyzed.
- Forty patients completed the study with follow-up assessments at three months and one year.
Main Results:
- Significant improvement in clinical symptoms, including reduced dyspnea and palpitations, was observed post-closure.
- Echocardiography showed minimal residual shunts that resolved by three months, with a significant decrease in right ventricular cavity size.
- Quality of life scores (SF-36) significantly improved at three months and were sustained at one year.
Conclusions:
- Transcatheter device closure is a safe and effective treatment for sexagenary patients with ASDs.
- The procedure leads to substantial improvements in clinical outcomes and subjective quality of life.
- This approach represents a favorable therapeutic option for older adults with atrial septal defects.
Introduction:
The objective of this study is to evaluate the efficacy and midterm prognosis of transcatheter device closure of atrial septal defects (ASDs) in sexagenary patients in China.
Methods:
Forty-six sexagenary patients who underwent transcatheter device closure of ASDs in our hospital were included in this study. The patients' preoperative and postoperative clinical symptoms, echocardiographic results, and quality of life were investigated and analyzed.
Results:
Of the 46 sexagenary patients who participated in the study, 40 completed the study. After ASD closure, the clinical symptoms of the patients significantly improved, and the number of patients with dyspnea and palpitations significantly decreased after the operation. According to the echocardiographic results, few patients had a tiny residual shunt after closure, but the shunt disappeared completely at the three-month follow-up. The size of the right ventricular cavity was significantly smaller postoperatively compared with preoperatively. Regarding the patients' quality of life, their feedback in all dimensions of the 36-Item Short-Form Health Survey (or SF-36) was significantly improved at the three-month follow-up, and it remained improved at the one-year follow-up.
Conclusion:
The clinical outcomes and subjective quality of life of sexagenary patients with ASDs improved significantly after transcatheter device closure of ASDs. Therefore, we believe that for sexagenary patients with ASDs, transcatheter device closure is a favorable treatment.
Related Concept Videos
01:26Mitral Stenosis III: Medical Management
01:26Aneurysm III: Interprofessional Care