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Area of Science:

  • Neurology
  • Toxicology
  • Integrative Medicine

Background:

  • Ozone-based treatments carry a risk of central nervous system toxicity, termed ozone-induced encephalopathy (OIE).
  • The precise clinical presentation and characteristics of OIE remain incompletely described.

Observation:

  • Three cases of OIE following ozone therapy (OT) are presented, involving neurological symptoms like altered consciousness, visual disturbances, and amnesia.
  • Magnetic resonance imaging (MRI) findings were initially normal or subtle, with one case showing cerebellar changes and a patent foramen ovale (PFO).
  • Eight additional OIE cases were identified in the literature, highlighting a pattern of neurological dysfunction post-OT.

Findings:

  • OIE manifests with diverse neurological symptoms immediately following ozone therapy.
  • Recovery is typically rapid, occurring within 48 hours for the presented cases.
  • The condition may be underreported due to its resemblance to other neurological disorders.

Implications:

  • OIE should be considered in patients experiencing neurological symptoms after ozone therapy.
  • OIE represents a potentially novel iatrogenic neurological condition.
  • Further research is needed to elucidate the pathogenesis and diagnostic criteria for OIE.