Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Imaging Studies for Cardiovascular System II:Types of Echocardiography01:20

Imaging Studies for Cardiovascular System II:Types of Echocardiography

470
Echocardiography plays a role in assessing cardiac health and detecting heart conditions, with various types providing critical insights for diagnosis and treatment.
Types of Echocardiography
Transthoracic Echocardiography (TTE)
TTE is the most common type of echocardiogram which involves placing a transducer on the patient's chest, emitting sound waves to create heart images. TTE is invaluable for evaluating the heart's size, structure, and motion, making it particularly useful for...
470
Imaging Studies for Cardiovascular System V: CT01:28

Imaging Studies for Cardiovascular System V: CT

138
Cardiac computed tomography (CT) scanning is an advanced cardiac imaging technique that utilizes CT technology, with or without intravenous (IV) contrast, to produce accurate cross-sectional virtual slices of specific areas of the heart, coronary circulation, and major blood vessels such as the aorta, pulmonary veins, and arteries. The computer processes these slices to generate three-dimensional images. Multidetector CT (MDCT) is a rapid form of CT scanning that captures multiple slices...
138
Imaging Studies VII: Vascular Imaging01:19

Imaging Studies VII: Vascular Imaging

131
DefinitionRenal angiography, also known as renal arteriography, is an imaging technique used to obtain a comprehensive view of blood flow and the vascular structure of blood vessels in the kidneys and surrounding areas.PurposeRenal angiography detects blood vessel abnormalities in the kidneys, such as aneurysms, stenosis, thrombosis, vascular tumors, and renal artery stenosis. It evaluates kidney function and guides interventional treatments like angioplasty or stent placement.Pre-Procedure...
131
Imaging Studies III: Computed Tomography01:27

Imaging Studies III: Computed Tomography

126
DefinitionComputed Tomography (CT) of the genitourinary (GU) tract is a non-invasive imaging modality that utilizes X-rays and computer processing to generate detailed cross-sectional images of the urinary system, encompassing the kidneys, ureters, bladder, and adjacent structures such as the adrenal glands.PurposeCT scans of the GU tract serve several diagnostic and therapeutic purposes, including:Diagnosis of Urinary Tract Diseases: Detects kidney stones, tumors, cysts, and congenital...
126

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Periodontitis aggravates bone loss through gut microbiota alterations in ovariectomized mice.

NPJ biofilms and microbiomes·2026
Same author

Periodontitis-associated gut microbiota disrupts glucose homeostasis through SCFAs depletion and inflammation in germ-free mice.

BMC oral health·2026
Same author

Membrane and bioenergetic dysfunction in Parkinson's disease with REM sleep behavior disorder: A <sup>31</sup>P and <sup>1</sup>H MR study.

NeuroImage·2026
Same author

Gut microbiota dysbiosis and metabolic alterations in rheumatoid arthritis: a barrier to periodontal repair.

RMD open·2026
Same author

Asymptomatic Abnormalities in the Knee, Shoulder, and Ankle Joints of Collegiate Athletes: A Cross-Sectional MRI-Based Comparative Study.

Diagnostics (Basel, Switzerland)·2026
Same author

Ultra-high resolution Photon-Counting CTA for follow-up assessment of intracranial aneurysms after flow diverter: Initial experience.

European journal of radiology·2026

Related Experiment Video

Updated: Nov 15, 2025

Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

12.9K

Phase retrieval-based phase-contrast CT for vascular imaging with microbubble contrast agent.

Rongbiao Tang1, Yongfang Li2, Le Qin1

  • 1Department of Radiology, Rui Jin Hospital, Shanghai Jiao Tong University, and School of Medicine, Shanghai, China.

Medical Physics
|March 3, 2021
PubMed
Summary

Phase retrieval-based phase-contrast computed tomography (PCCT) with microbubble contrast agents shows promise for vascular imaging. This method offers superior contrast enhancement compared to conventional CT, enabling clear visualization of rat arterial systems.

Keywords:
microbubblesphase retrievalphase-contrast CTsynchrotron radiationvascular imaging

More Related Videos

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of &#946;-aminopropionitrile-induced Aortic Aneurysm and Dissection
06:46

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Published on: July 16, 2018

9.8K
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.5K

Related Experiment Videos

Last Updated: Nov 15, 2025

Contrast Enhanced Vessel Imaging using MicroCT
05:50

Contrast Enhanced Vessel Imaging using MicroCT

Published on: January 27, 2011

12.9K
Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of &#946;-aminopropionitrile-induced Aortic Aneurysm and Dissection
06:46

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of β-aminopropionitrile-induced Aortic Aneurysm and Dissection

Published on: July 16, 2018

9.8K
Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease
08:41

Novel In Vivo Micro-Computed Tomography Imaging Techniques for Assessing the Progression of Non-Alcoholic Fatty Liver Disease

Published on: March 24, 2023

1.5K

Area of Science:

  • Medical Imaging
  • Biomedical Engineering
  • X-ray Physics

Background:

  • Microbubble contrast agents induce phase shifts in tissues, detectable by phase retrieval (PR).
  • Phase-contrast computed tomography (PCCT) reconstructs these phase shifts for imaging.
  • Evaluating PR-based PCCT with microbubbles is crucial for advancing vascular imaging techniques.

Purpose of the Study:

  • To assess the feasibility of using PR-based PCCT with microbubble contrast agents for vascular imaging.
  • To compare the contrast enhancement of microbubbles with iodine contrast agents in vitro.
  • To evaluate the performance of PR-based PCCT for visualizing rat arterial systems ex vivo.

Main Methods:

  • Captured projection phase-contrast images of microbubbles.
  • Conducted in vitro experiments comparing microbubbles to iodine contrast agents.
  • Performed ex vivo CT imaging of rat arterial systems perfused with microbubbles or saline at 22 keV.
  • Utilized the phase-attenuation duality (PAD) method for phase retrieval.
  • Quantified contrast enhancement using contrast-to-noise ratio (CNR).

Main Results:

  • Individual microbubbles focused X-rays, while clusters scattered them.
  • Iodine contrast yielded significantly higher enhancement than microbubbles in vitro (P < 0.05).
  • PR-based PCCT showed significantly higher CNRs for microbubbles than ACCT and PR-free PCCT (P < 0.001).
  • Microbubbles in PR-based PCCT provided significantly greater CNR than saline (P < 0.001).
  • Microbubbles enabled clear 3D visualization of rat aortas and branches, despite weaker contrast than iodine.

Conclusions:

  • PR-based PCCT with microbubbles is a feasible technique for vascular imaging.
  • The method offers superior contrast compared to absorption-contrast CT and PR-free PCCT.
  • This modality serves as a valuable complement or alternative to absorption-based microCT for imaging vessels in biological samples.