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Bead Aggregation Assays for the Characterization of Putative Cell Adhesion Molecules
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Cadherin cis and trans interactions are mutually cooperative.

Connor J Thompson1, Vinh H Vu2, Deborah E Leckband2,3

  • 1Department of Chemical and Biological Engineering, University of Colorado, Boulder, CO 80309.

Proceedings of the National Academy of Sciences of the United States of America
|March 4, 2021
PubMed
Summary

Cadherin proteins mediate cell adhesion through cis and trans interactions. This study provides the first experimental evidence that these interactions mutually cooperate, strengthening cell adhesions.

Keywords:
FRETadherens junctionscadherincell adhesionsingle-molecule tracking

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