A Study on the Correlation Between MDR1 Polymorphism and Clopidogrel Resistance in Hui Patients Treated with
Fang Chen1, Jing Zhang2, Cheng-Xue Bian2
1Department of Cardiology, Yinchuan First People's Hospital, Yinchuan, People's Republic of China.
Insights
The T allele of the MDR1 gene C3435T is linked to clopidogrel resistance (CR) in Hui patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI). This finding aids in predicting CR risk in this population.
Area of Science:
- Pharmacogenomics
- Cardiovascular Medicine
- Genetic Epidemiology
Background:
- Clopidogrel resistance (CR) is a significant concern in patients with coronary heart disease (CHD) undergoing percutaneous coronary intervention (PCI).
- The MDR1 gene plays a role in drug transport and metabolism, potentially influencing clopidogrel efficacy.
- Genetic variations, specifically polymorphisms, may predispose certain ethnic groups to CR.
Purpose of the Study:
- To investigate the association between MDR1 gene polymorphisms (C3435T and C1236T) and clopidogrel resistance (CR).
- To assess the prevalence of CR in Hui patients with CHD treated with PCI.
Main Methods:
- A cohort of 204 Hui patients with CHD undergoing PCI was studied.
- Patients were classified as clopidogrel resistant (CR) or non-clopidogrel resistant (NCR) based on post-operative platelet aggregation rates.
- MDR1 gene C3435T and C1236T genotypes and alleles were analyzed using polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Main Results:
- The overall CR rate was 24.0%.
- A significantly higher frequency of the 3435TT genotype and T allele of the MDR1 C3435T polymorphism was observed in the CR group compared to the NCR group.
- No significant association was found between the MDR1 C1236T polymorphism and CR.
Conclusions:
- The T allele of the MDR1 C3435T gene polymorphism is a potential predictor of clopidogrel resistance in Hui patients with CHD treated with PCI.
- These findings highlight the importance of pharmacogenetic considerations in clopidogrel therapy for specific ethnic populations.
Objective:
This study assesses the correlation between MDR1 gene polymorphism and clopidogrel resistance (CR) in Hui patients with coronary heart disease (CHD) who were treated with percutaneous coronary intervention (PCI).
Methods:
The study includes 204 Ningxia Hui patients with CHD who were treated with PCI. These patients were divided into two groups: those who with CR and others were non-clopidogrel resistant (NCR), according to the results of the patients' platelet aggregation rate, which was tested by adenosine diphosphate-induced turbidimetry on the second postoperative day. C3435T and C1236T genotypes and alleles were tested by polymerase chain reaction-restriction fragment length polymorphism (PCR-RFLP).
Results:
The CR rate was 24.0%, and there were 3 genotypes of C3435T and C1236T. For C3435T, the distribution frequency of the 3435TT genotype and T allele was significantly higher in the CR group than in the NCR group. For C1236T, no significant difference was found between the two groups.
Conclusion:
Hui patients who had CHD were treated with PCI. CR was most likely to occur in those who had the T allele of MDR1 in gene C3435T.
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