Related Experiment Video

Updated: Nov 15, 2025

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model
08:22

In vitro Assessment of Myocardial Protection following Hypothermia-Preconditioning in a Human Cardiac Myocytes Model

Published on: October 27, 2020

3.3K

Effects of Therapeutic Hypothermia on Normal and Ischemic Heart

Kelly P Yamada1, Taro Kariya1, Tadao Aikawa1

  • 1Cardiovascular Research Institute, Icahn School of Medicine at Mount Sinai, New York, NY, United States.

Frontiers in Cardiovascular Medicine
|March 4, 2021
PubMed

Insights

Therapeutic hypothermia shows promise for reducing heart damage after myocardial infarction. Rapid cooling techniques are being investigated in new clinical trials to assess its effectiveness.

Area of Science:

  • Cardiology
  • Cardiovascular Research
  • Therapeutic Hypothermia

Background:

  • Therapeutic hypothermia is established for treating brain injury following cardiac arrest.
  • Its efficacy in minimizing myocardial ischemic injury requires further clinical validation.
  • Hypothermia for myocardial infarction can be initiated before reperfusion, unlike its use in brain injury.

Purpose of the Study:

  • To review the current understanding of hypothermia's effects on normal and ischemic hearts.
  • To discuss challenges and future directions for clinical application in acute myocardial infarction.

Main Methods:

  • Review of preclinical and clinical studies on therapeutic hypothermia for myocardial infarction.
  • Analysis of advancements in cooling technology for rapid cardiac cooling.
  • Discussion of existing knowledge gaps and clinical trial designs.

Main Results:

  • Preclinical studies suggest potential benefits of hypothermia for myocardial ischemic injury.
  • Clinical evidence confirming these benefits is still limited.
  • Advancements in cooling technology enable faster cardiac cooling, supporting new trials.

Conclusions:

  • Therapeutic hypothermia holds potential for treating acute myocardial infarction.
  • Further research and clinical trials are necessary to confirm efficacy and optimize application.
  • Overcoming current challenges is crucial for successful clinical implementation.

Keywords:
cardiac functionclinical trialendovascularhypothermiainfarct sizemyocardial infarctionphysiologypreclinical

More Related Videos

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms05:00

Short-Duration Hypothermia Induction in Rats using Models for Studies examining Clinical Relevance and Mechanisms

Published on: March 3, 2021

3.2K
Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management06:43

Esophageal Heat Transfer for Patient Temperature Control and Targeted Temperature Management

Published on: November 21, 2017

24.7K

Related Concept Videos

Decreased Body Temperature01:29

Decreased Body Temperature

A decreased body temperature can occur in patients with hypothermia and frostbite. Heat loss with extended cold exposure overpowers the body's ability to create heat, resulting in hypothermia. Core temperature readings help classify hypothermia. Mild hypothermia is temperatures between 32 °C (89.6 °F) and 35°C (95 °F) and is caused by impaired thermoregulation. Moderate hypothermia is temperatures between 28 C (82.4 °F) and 32 °C (89.6 °F) caused by...
806
Ischemic Heart Disease: Overview01:17

Ischemic Heart Disease: Overview

Ischemic heart disease occurs when the heart's blood supply dwindles, causing an ominous lack of oxygen and nutrients. This deficiency, stemming from reduced or obstructed blood flow, spells danger, leading to heart muscle damage and dysfunction.
Atherosclerosis, the primary malefactor, orchestrates this dangerous condition. It manifests as the accumulation of fatty deposits, akin to insidious plaques, within arterial walls. As time elapses, these plaques metamorphose, hardening and...
2.3K
Homeostatic Imbalances in Body Temperature01:19

Homeostatic Imbalances in Body Temperature

Hyperthermia occurs when the body's temperature becomes unusually high, often due to heat exposure, intense physical activity, or certain illnesses. This condition can create a dangerous cycle where elevated body temperature increases the metabolic rate, generating more heat and potentially leading to organ failure and brain damage. A severe form of hyperthermia, called heat stroke, can raise body temperature to life-threatening levels. Fever, on the other hand, is a controlled form of...
2.1K