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The Discrete Paired-trial Variable-delay T-maze Task to Assess Working Memory in Mice
Gian Marco Leggio1, Sebastiano Alfio Torrisi1, Francesco Papaleo2
1Department of Biomedical and Biotechnological Sciences, University of Catania, Catania, Italy.
Bio-Protocol
|March 4, 2021
Summary
Working memory deficits in schizophrenia, linked to the prefrontal cortex, are a major challenge. Rodent models using the T-maze task can effectively study these prefrontal cortex-dependent working memory issues.
Area of Science:
- Neuroscience
- Psychiatry
- Cognitive Science
Background:
- Working memory impairments involving the prefrontal cortex (PFC) are a significant issue in schizophrenia, leading to poor functional outcomes.
- Rodent models are crucial for understanding the mechanisms of PFC-dependent working memory dysfunction and for testing potential therapies.
Purpose of the Study:
- To highlight the importance of using appropriate behavioral tasks to assess PFC-dependent working memory in rodents.
- To introduce the discrete paired-trial variable-delay T-maze task as a valid tool for studying working memory in schizophrenia models.
Main Methods:
- The discrete paired-trial variable-delay T-maze task was employed.
- This task is analogous to human delayed non-match to sample tasks.
Main Results:
- The T-maze task has demonstrated effectiveness in assessing PFC-dependent working memory.
- This paradigm shows high predictive validity for human studies.
Conclusions:
- The discrete paired-trial variable-delay T-maze task is a valuable tool for preclinical research in schizophrenia.
- This task facilitates the study of PFC-dependent working memory deficits and aids in the development of targeted therapeutic strategies.
Keywords:
Animal modelsCognitive dysfunctionsDiscrete paired-trial variable-delay T-mazeSchizophreniaWorking memory
