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Related Experiment Videos

Examining Cocaine Conditioning Place Preference in Mice.

MaryElizabeth J Simkevich1,2, Rianne R Campbell3, André O White1,2

  • 1Biological Sciences, Mount Holyoke College, South Hadley, MA USA.

Bio-Protocol
|March 4, 2021
PubMed
Summary

The conditioned place preference (CPP) task effectively measures drug reward in mice with minimal training and no surgery. This method aids in understanding substance use disorders by assessing cocaine

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Area of Science:

  • Neuroscience
  • Behavioral Pharmacology
  • Addiction Research

Background:

  • Understanding drug reward mechanisms is crucial for treating substance use disorders.
  • Traditional methods like self-administration require extensive training and surgery.
  • Existing methods may be confounded by anesthesia or analgesics.

Purpose of the Study:

  • To present the conditioned place preference (CPP) task as an efficient method for assessing drug reward.
  • To highlight the advantages of the CPP task over other behavioral paradigms.

Main Methods:

  • The CPP task involves pretest, conditioning, and posttest phases in a three-compartment apparatus.
  • Mice receive cocaine or saline and are confined to specific compartments to establish an association.
Keywords:
BehaviorCocaineConditioned place preferenceMouseReward

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  • Locomotor activity and time spent in compartments are recorded during drug-free exploration.

    • Main Results:

    • Enhancements in CPP scores indicate the rewarding properties of the drug.
    • The three-compartment design minimizes bias compared to two-compartment setups.
    • Multimodal cues facilitate robust preference acquisition across different mouse strains.

    Conclusions:

    • The CPP task is a valuable, low-training, non-surgical method for assessing drug reward.
    • It allows for simultaneous measurement of locomotor activity and reward.
    • This task provides a reliable model for addiction research.