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Updated: Nov 15, 2025

Author Spotlight: Advancing Research on Candida albicans Biofilm-Associated Prosthetic Joint Infections
Published on: February 2, 2024
Single-Stage Revision With Fluconazole Monotherapy in Fungal Prosthetic Knee Joint Infections
James C George1, Jishar Sainulabdeen1, Samuel Chittaranjan1
1Department of Orthopaedics, Believer's Church Medical College and Hospital, Thiruvalla, Kerala, India.
Abstract:
Fungal prosthetic joint infection is rare, and two-stage revision is usually advocated. We present our experience with 2 cases of fungal prosthetic knee joint infection presenting 25 months and 3 years after index surgery. Both patients were managed with single-stage revision arthroplasty and fluconazole monotherapy. They remain asymptomatic with good knee society score after 2 years of follow-up. Preoperative workup of all aseptic loosening cases should include extended culture for fungal elements. Single-stage revision with antifungal therapy for 3 months gives good results in nonimmunocompromised patients with good soft-tissue envelope.
Insights
Fungal prosthetic joint infections are rare. This study shows single-stage revision arthroplasty with antifungal therapy can be effective for non-immunocompromised patients.
Area of Science:
- Orthopedic Surgery
- Infectious Diseases
- Mycology
Background:
- Fungal prosthetic joint infection (PJI) is an uncommon but serious complication following joint replacement surgery.
- Traditional management often involves a two-stage revision procedure, which can be lengthy and demanding for patients.
- The optimal treatment strategy for fungal PJI, particularly in non-immunocompromised individuals, requires further investigation.
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