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Related Experiment Videos

Comparison of colophony patch test preparations.

A T Karlberg1, C Lidén

  • 1Department of Occupational Dermatology, National Institute of Occupational Health, Solna, Sweden.

Contact Dermatitis
|March 1, 1988
PubMed
Summary
This summary is machine-generated.

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This study compared patch test reactivity to colophony (gum rosin) preparations. A 10% concentration is recommended for routine testing, showing a clear dose-response and avoiding irritancy seen with higher concentrations.

Area of Science:

  • Dermatology
  • Allergology
  • Contact Dermatitis

Background:

  • Colophony (gum rosin) is a common contact allergen.
  • Standardized patch testing concentrations are crucial for accurate diagnosis.

Purpose of the Study:

  • To compare patch test reactivity to various colophony concentrations and preparations.
  • To determine the optimal concentration of colophony for routine patch testing.

Main Methods:

  • Serial dilution patch testing of colophony from 20% to 0.001%.
  • Comparison of commercial and laboratory-prepared colophony test solutions.
  • Evaluation of dose-response relationship and irritancy.

Main Results:

  • A clear dose-response relationship was observed, with maximal reactivity at 10% and 20% colophony.

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  • Testing with 60% colophony did not identify additional positive cases compared to 20% and caused irritancy.
  • Good correlation between commercial and laboratory preparations was found.

    • Conclusions:

    • A 10% concentration of colophony is suggested for routine patch testing.
    • This concentration balances diagnostic sensitivity with reduced irritancy potential.