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Updated: Nov 15, 2025

Author Spotlight: Advancing Male Infertility Research by Unraveling Sperm Metabolism and Mitochondrial Function
Published on: June 23, 2023
Recent advances and controversies in diagnosing and treating male infertility
Rafael F Ambar1,2,3, Neel Parekh1, Ashok Agarwal1
1American Center for Reproductive Medicine, Cleveland Clinic, Cleveland, OH, USA.
Abstract:
Interest in male infertility has increased, as it plays an important role in up to 50% of couples struggling with infertility, which is an estimated 48.5 million couples globally. Despite recent advances, diagnosing and treating male infertility remain a significant clinical challenge owing to complex multifactorial pathways and the diversity of treatment options. This review will assess current controversial topics on male infertility such as the use of home-based semen testing, management of subclinical varicocele, and recent advances in the field of sperm proteomics.
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