Efficient dispersive micro solid-phase extraction of antidepressant drugs by a robust molybdenum-based coordination...

Area of Science:

• Materials Chemistry
• Analytical Chemistry
• Separation Science

Background:

• Molybdenum-based coordination polymers offer unique structural and electronic properties.
• Developing efficient sorbent materials is crucial for trace analysis of pharmaceuticals in complex matrices.
• Dispersive micro solid-phase extraction (D-μSPE) is a sensitive technique for sample preparation.

Purpose of the Study:

• To synthesize and characterize a novel molybdenum-based coordination polymer.
• To evaluate its performance as a sorbent for D-μSPE of antidepressant drugs.
• To develop and validate a D-μSPE-HPLC-UV method for antidepressant determination in human plasma.

Main Methods:

• Solvothermal synthesis of the molybdenum coordination polymer {[Mo(PDA)(NO)(μ-O)MoO3]·1.42H2O·0.58C2H5OH}n.
• Structural characterization using single-crystal X-ray diffraction.
• Application in D-μSPE for antidepressant extraction, followed by HPLC-UV analysis.

Main Results:

• The synthesized material exhibits a 1D chain structure with 3D expansion via π-interactions and hydrogen bonding.
• The coordination polymer demonstrated excellent adsorption capacity and selectivity for basic organic compounds like antidepressants.
• The D-μSPE-HPLC-UV method achieved good linearity (0.1-500 ng mL⁻¹), low LODs (0.03-0.2 ng mL⁻¹), and high recoveries (94.9-102%) in human plasma.
• The sorbent showed high stability and reusability over 20 cycles.

Conclusions:

• The synthesized molybdenum coordination polymer is a robust and effective sorbent for D-μSPE.
• The developed D-μSPE-HPLC-UV method is suitable for the sensitive and accurate determination of antidepressant drugs in human plasma.
• This approach offers a promising tool for pharmaceutical analysis and clinical monitoring.