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Tissue Transplantation

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Tissue transplantation is a significant medical procedure involving the transfer of cells, tissues, or organs from a donor to a recipient, with the primary aim of restoring lost functions. This procedure is crucial in treating a broad spectrum of diseases, including kidney diseases, liver failure, heart disease, and certain types of cancers.
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Updated: Nov 15, 2025

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

MitoCeption: Transferring Isolated Human MSC Mitochondria to Glioblastoma Stem Cells

Published on: February 22, 2017

One step forward: extracellular mitochondria transplantation.

Lucia-Doina Popov¹

¹Institute of Cellular Biology and Pathology "Nicolae Simionescu" of the Romanian Academy, 8, B.P. Hasdeu Street, 050568, Bucharest, Romania. doina.popov@icbp.ro.

Cell and Tissue Research

|March 4, 2021

Summary

Mitochondrial transplantation involves using healthy, extracellular mitochondria to replace damaged ones, offering potential cardioprotective and neuroprotective effects in various diseases. Further research is needed to establish efficacy across different settings.

Keywords:

Ischemia reperfusion injury Macropinocytosis Mitochondrial dysfunction Neurodegeneration Parkinson’s disease

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Area of Science:

Cell Biology
Mitochondrial Medicine
Regenerative Medicine

Background:

Mitochondria are vital for cellular energy and homeostasis.
Extracellular mitochondria, released from cells like platelets and astrocytes, are found in bodily fluids.
Mitochondrial dysfunction is linked to cardiovascular and neurodegenerative diseases.

Purpose of the Study:

To critically review current and future trends in mitochondrial transplantation.
To explore the roles and types of extracellular mitochondria.
To assess the efficacy and mechanisms of mitochondrial transplantation in health and disease.

Main Methods:

Review of recent developments in extracellular mitochondria research.
Analysis of mitochondrial transplantation protocols and incorporation mechanisms.
Evaluation of benefits in various health and disease models.

Main Results:

Extracellular mitochondria have diverse roles and are present in circulation and cerebrospinal fluid.
Mitochondrial transplantation is explored as a therapeutic strategy for damaged tissues.
Variable efficacy has been reported across in vitro, animal, and patient studies, indicating a lack of consensus.

Conclusions:

Mitochondrial transplantation holds promise for treating conditions associated with mitochondrial dysfunction.
Further research is essential to clarify transplantation protocols, mechanisms, and clinical benefits.
Addressing open questions is crucial for advancing this therapeutic strategy.