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07:44
A Porcine Model of Acute Autologous Pulmonary Embolism
Published on: September 6, 2024
627
Time interval between E and E' waves can predict complicated clinical course in patients with acute pulmonary
Emrah Acar1, Alev Kilicgedik2, Servet Izci2
1Department of Cardiology, Gumushane State Hospital, Gumushane, Turkey.
Journal of Clinical Ultrasound : JCU
|March 4, 2021
Summary
Right ventricle diastolic function assessment can predict complicated clinical courses in acute pulmonary embolism patients. Key echocardiographic measures, like the time interval between early and late diastolic filling (TE-E') predict adverse outcomes.
Area of Science:
- Cardiology
- Pulmonary Medicine
- Diagnostic Imaging
Background:
- Acute pulmonary embolism (PE) is a critical condition impacting right ventricle (RV) function.
- RV systolic and diastolic dysfunction are key indicators of PE severity and prognosis.
Purpose of the Study:
- To investigate RV diastolic function in acute PE patients.
- To determine the predictive value of RV diastolic indices for clinical course complications.
Main Methods:
- Prospective study of 448 acute PE patients.
- Transthoracic echocardiography to assess RV systolic and diastolic indices.
- 30-day follow-up to categorize patients into benign or complicated clinical course groups.
Main Results:
- Patients with complicated courses showed altered RV diastolic parameters, including higher E/E' and shorter isovolumetric relaxation time (IVRT).
- The time interval between early and late diastolic filling (TE-E") demonstrated the highest predictive accuracy (AUC=0.82) for complicated outcomes.
- A TE-E" cutoff of 70 milliseconds predicted complicated clinical course with 81.1% sensitivity and 71.4% specificity.
Conclusions:
- RV diastolic function assessment is a valuable tool for predicting clinical course in acute PE.
- Echocardiographic parameters, particularly TE-E", can identify high-risk patients requiring closer monitoring.
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