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Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
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Asthma is a chronic respiratory condition for which new therapeutic avenues, including anti-inflammatory drugs like mast cell stabilizers and anti-IgE treatments, continue to be developed.
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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Author Spotlight: Investigating the Pathophysiology of Eosinophilic Esophagitis
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Eosinophilic sialodochitis: An emerging atopic condition.

Barbara Carey1, Niall O'Neill2, Jackie Brown2

  • 1Oral Medicine, Guy's and St. Thomas Hospital NHS Foundation Trust, London, UK.

Oral Diseases
|March 4, 2021
PubMed
Summary

Eosinophilic sialodochitis often presents as recurrent salivary gland swelling. This study details the largest cohort, highlighting clinical features and potential allergic links.

Keywords:
allergic parotitiseosinophiliaeosinophilic sialodochitissalivary glandssialodochitis fibrinosa

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Area of Science:

  • Otorhinolaryngology
  • Allergy and Immunology
  • Pathology

Background:

  • Eosinophilic sialodochitis is a rare condition affecting salivary glands.
  • Understanding its clinical presentation is crucial for diagnosis and management.

Purpose of the Study:

  • To describe the clinical characteristics of the largest single-center cohort of patients diagnosed with eosinophilic sialodochitis.
  • To identify key demographic, clinical, and laboratory features associated with the condition.

Main Methods:

  • Retrospective analysis of 37 patients from a multidisciplinary clinic.
  • Collated demographic, clinical, hematological, cytological, histological, and radiological data.
  • Assessed patient response to allergy-focused treatments.

Main Results:

  • 37 patients (7 male, 30 female) identified, with a mean age of 50.4 years.
  • Common symptoms included swelling (97%), itching (92%), discomfort (84%), and "string-like" mucus discharge (76%).
  • Atopic disease (62%) and elevated serum IgE (57%) were frequent; eosinophils were present in duct samples (100%) and elevated in peripheral counts (41%).

Conclusions:

  • Eosinophilic sialodochitis should be considered in patients with recurrent salivary gland swelling.
  • The findings suggest a likely allergic pathogenesis, warranting further investigation into targeted treatments.