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Targetable pathogenic mechanisms in nasal polyposis

Alexander L Schneider1, Robert P Schleimer1,2, Bruce K Tan1,2

  • 1Department of Otolaryngology, Head and Neck Surgery, Chicago, Illinois, USA.

International Forum of Allergy & Rhinology
|March 4, 2021
PubMed

Insights

Chronic rhinosinusitis with nasal polyps (CRSwNP) is a complex condition. This review explores new targeted therapies beyond type 2 inflammation for CRSwNP, examining ongoing clinical studies.

Area of Science:

  • Immunology
  • Otolaryngology
  • Pharmacology

Background:

  • Chronic rhinosinusitis with nasal polyps (CRSwNP) frequently recurs despite treatment.
  • Current CRSwNP biologics target type 2 inflammation, but other pathways may be involved.

Purpose of the Study:

  • To review pathogenic mechanisms in CRSwNP.
  • To discuss ongoing clinical trials of targeted therapeutics for CRSwNP.

Main Methods:

  • Literature review of CRSwNP pathophysiology.
  • Analysis of ongoing clinical studies for targeted therapies.
  • Exploration of therapeutic targets in related inflammatory diseases.

Main Results:

  • Type 2 inflammation is a primary target of current CRSwNP biologics.
  • Other inflammatory pathways in CRSwNP warrant investigation for targeted therapies.
  • Clinical trials are evaluating novel targeted agents for CRSwNP.

Conclusions:

  • Understanding diverse CRSwNP pathogenic mechanisms is crucial.
  • Targeted therapeutics beyond type 2 inflammation hold promise for CRSwNP treatment.
  • Further research into non-type 2 pathways may yield new therapeutic options.
Keywords:
biologic therapieschronic rhinosinusitis with nasal polypstype 2 inflammation

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