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Area of Science:

  • Gastroenterology
  • Metabolic Health
  • Microbiome Research

Background:

  • Investigating long-term metabolic and microbiota changes after upper and lower GI surgery.
  • Comparing surgical patients with a control group.

Purpose of the Study:

  • To assess the long-term effects of total gastrectomy with Roux-en-Y esophagojejunostomy (RYEJ) and partial colectomy with right hemicolectomy (RH) on metabolic syndrome and gut microbiota.
  • To compare these outcomes with age- and sex-matched controls.

Main Methods:

  • Cross-sectional study analyzing metabolic syndrome occurrence in 10 RYEJ, 11 RH patients, and 33 controls.
  • Fecal sample analysis using next-generation sequencing to assess gut microbiota composition.

Main Results:

  • Metabolic syndrome was significantly lower in RYEJ patients (>8 years post-op) vs. controls (p < 0.05).
  • RH patients showed a trend toward higher fasting glucose (p = 0.10).
  • Gut microbiota diversity decreased after RH (p < 0.05). Significant differences in microbiota composition were found between groups (p < 0.001). The Prevotella/Bacteroides (P/B) ratio was higher in RYEJ and lower in RH groups vs. controls (p < 0.05).

Conclusions:

  • Total gastrectomy (RYEJ) is associated with reduced long-term metabolic syndrome occurrence.
  • Partial colectomy (RH) is linked to higher long-term fasting glucose.
  • Altered gut microbiota P/B ratios parallel the metabolic changes observed after upper and lower GI surgery.