Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

[Vasoactive intestinal polypeptide influences human immunoglobulin secretion].

R Hart1, H Dancygier

  • 1II. Medizinische Klinik und Poliklinik, Technische Universität München, Klinikum rechts der Isar.

Deutsche Medizinische Wochenschrift (1946)
|May 13, 1988
PubMed
Summary

Vasoactive intestinal polypeptide (VIP) significantly boosted IgM secretion in human lymphocytes stimulated with Pokeweed mitogen. This demonstrates VIP

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Acute-on-chronic liver failure.

BJA education·2025
Same author

Canadian Surgery Forum: Abstracts of presentations to the Annual Meetings of the Canadian Association of Bariatric Physicians and Surgeons, Canadian Association of General Surgeons, Canadian Association of Thoracic Surgeons, Canadian Hepato-Pancreato-Biliary Association, Canadian Society of Surgical Oncology, Canadian Society of Colon and Rectal Surgeons, Vancouver, BC, Sept. 17-21, 2013.

Canadian journal of surgery. Journal canadien de chirurgie·2025
Same author

Chewing analysis of horses consuming bermudagrass hay in different styles of slow feeders as compared to loose hay.

Journal of equine veterinary science·2024
Same author

Behavioural, developmental and psychological characteristics in children with germline PTEN mutations: a carer report study.

Journal of intellectual disability research : JIDR·2024
Same author

The association between <i>in utero</i> exposure to maternal psychological stress and female reproductive function in adolescence: A prospective cohort study.

Comprehensive psychoneuroendocrinology·2022
Same author

Specimen oriented intraoperative margin assessment in oral cavity and oropharyngeal squamous cell carcinoma.

Journal of otolaryngology - head & neck surgery = Le Journal d'oto-rhino-laryngologie et de chirurgie cervico-faciale·2021

Area of Science:

  • Immunology
  • Neuroendocrinology

Background:

  • Vasoactive intestinal polypeptide (VIP) is a neuropeptide found in the intestinal mucosa.
  • Local immune responses in the gut are complex and involve interactions between various cell types and signaling molecules.

Purpose of the Study:

  • To investigate the effect of VIP on human immunoglobulin synthesis in vitro.
  • To determine if VIP influences lymphocyte activation and antibody production.

Main Methods:

  • Human peripheral blood lymphocytes were cultured for seven days.
  • Cells were stimulated with Pokeweed mitogen and varying concentrations of VIP (10(-12) M to 10(-6) M).
  • Immunoglobulin M (IgM) concentrations were measured using ELISA.

Main Results:

Related Experiment Videos

  • VIP significantly enhanced Pokeweed mitogen-induced IgM secretion in a dose-dependent manner in six out of eight subjects.
  • VIP did not affect IgM secretion in non-mitogen-stimulated cells.
  • This study provides the first evidence of VIP influencing human immunoglobulin synthesis in vitro.

Conclusions:

  • VIP, at concentrations found in the intestinal mucosa, can modulate human immunoglobulin synthesis.
  • These findings contribute to understanding local immunoregulatory mechanisms in the gut.
  • VIP may play a role in intestinal mucosal immunity.