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The interplay between vitamin D and COVID-19: protective or bystander?
H F Hetta1, K Muhammad, E A El-Masry
1Department of Medical Microbiology and Immunology, Faculty of Medicine, Assiut University, Assiut, Egypt. k.muhammad@uaeu.ac.ae.
European Review for Medical and Pharmacological Sciences
|March 4, 2021
Summary
Vitamin D may reduce the risk of severe COVID-19 (Coronavirus Disease-2019). Individuals with vitamin D deficiency should consider supplementation to maintain optimal levels and support immune function against viral infections.
Area of Science:
- Immunology
- Nutritional Science
- Public Health
Background:
- The COVID-19 pandemic, caused by SARS-CoV-2, necessitates strategies to mitigate infection severity and mortality.
- Vitamin D deficiency is associated with increased susceptibility to viral infections, including COVID-19.
Purpose of the Study:
- To review the potential roles of vitamin D in reducing COVID-19 infection risk and severity.
- To explore mechanisms by which vitamin D modulates the immune system against infections.
Main Methods:
- Literature review of clinical and epidemiological studies.
- Analysis of scientific literature on vitamin D's immunological functions.
Main Results:
- Vitamin D deficiency is linked to higher COVID-19 risk and severity.
- Vitamin D influences innate and adaptive immunity, potentially offering protection against viral infections.
Conclusions:
- Individuals at risk of vitamin D deficiency should consider supplementation to achieve optimal levels.
- Further research is warranted to confirm vitamin D's role in reducing COVID-19 incidence and mortality.
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