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Published on: August 26, 2014
Importance of Thalamostriatal Pathway Associated With Neurocognitive Dysfunctions in Children With Neurofibromatosis
Dilek Hacer Cesme1, Sinem Aydin2, Alpay Alkan1
1From the Department of Radiology, Faculty of Medicine, Bezmialem Vakif University.
Objective:
To determine whether there is a difference between healthy control group and children with neurofibromatosis type 1 (NF1) in terms of apparent diffusion coefficient (ADC) and fractional anisotropy (FA) values in different regions of the brain associated with neurocognitive functions and to investigate the correlation between diffusion tensor imaging parameters and neurocognitive dysfunctions.
Methods:
The study included 28 children with NF1 and 21 controls. Nine distinct areas related to cognitive functions were selected for the analysis. The ADC and FA values were compared.
Results:
There was a significant difference between NF1 and healthy control in terms of ADC values obtained from all areas. The ADC values at obtained from thalamus and striatum were positively correlated with the full-scale intelligence quotient (IQ), verbal IQ, and performance IQ.
Conclusions:
We are speculated that the development of microstructural damage in the thalamostriatal pathway may lead to neurocognitive dysfunction.
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