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Updated: Nov 15, 2025

Echocardiographic Approaches and Protocols for Comprehensive Phenotypic Characterization of Valvular Heart Disease in Mice
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Accuracy of Diastolic Function by Cardiac Computed Tomography Relative to Echo-Doppler: Additive Clinical and

Hayley-Ann van der Veen1, Jonathan Lessick, Sobhi Abadi2

  • 1From the Technion-Israel Institute of Technology.

Journal of Computer Assisted Tomography
|March 4, 2021
PubMed

Insights

Cardiac computed tomography (CT) shows good agreement with echocardiography for diagnosing advanced diastolic dysfunction (DD). CT-derived left atrial total emptying fraction is a strong predictor of cardiac events.

Area of Science:

  • Cardiology
  • Medical Imaging
  • Diagnostic Techniques

Background:

  • Diastolic dysfunction (DD) is a key indicator of cardiac health.
  • Echocardiography is the standard for assessing DD, but advanced cases can be challenging.
  • Cardiac computed tomography (CT) offers novel imaging capabilities for cardiac assessment.

Purpose of the Study:

  • To evaluate the agreement between cardiac CT and echocardiography in diagnosing advanced diastolic dysfunction (DD).
  • To determine the prognostic value of CT-derived parameters for predicting adverse cardiac outcomes.

Main Methods:

  • 101 patients with concurrent CT and echocardiography within one month were analyzed.
  • Diastolic function was assessed using CT based on left atrial volume changes.
  • Patients were followed for cardiac death and heart failure hospitalization.

Main Results:

  • Left atrial total emptying fraction on CT best predicted advanced DD, with 76% sensitivity and 86% specificity.
  • Agreement between CT and echocardiography for advanced DD (grades 2/3) was substantial (κ = 0.62).
  • Left atrial total emptying fraction independently predicted adverse outcomes at 3 years (HR 8.0).

Conclusions:

  • CT-based assessment of diastolic dysfunction (DD) aligns well with echocardiography.
  • Left atrial total emptying fraction derived from CT holds significant prognostic value for cardiac events.
Abstract

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