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IKZF1 Rs4132601 Polymorphism and Susceptibility to Acute Lymphocytic Leukemia in Children: A Meta-analysis
Xue Wu1, Mengyi Liu1, Qin Wang2
1Departments of Pediatric Preventive Health.
Insights
The IKZF1 rs4132601 polymorphism is linked to childhood acute lymphoblastic leukemia (ALL). T alleles and specific genotypes (TT, TT+TG, TG) are associated with a reduced risk of developing childhood ALL.
Area of Science:
- Genetics
- Oncology
- Pediatrics
Background:
- The IKZF1 rs4132601 polymorphism has been investigated for its association with childhood acute lymphoblastic leukemia (ALL).
- Previous studies reported inconsistent findings regarding this genetic link.
Purpose of the Study:
- To conduct a meta-analysis investigating the association between the IKZF1 rs4132601 polymorphism and susceptibility to childhood ALL.
- To consolidate existing evidence and provide a more robust conclusion on the genetic risk.
Main Methods:
- A comprehensive literature search was performed across multiple databases (PubMed, EMBASE, Web of Science, etc.) up to December 2019.
- Case-control studies were included, and meta-analysis was conducted using Stata 15.0.
- Analysis included calculation of odds ratios (OR) and confidence intervals (CI), with subgroup, sensitivity, and publication bias assessments.
Main Results:
- Nine studies comprising 2281 children with ALL and 2923 controls were analyzed.
- A significant association was found in the allelic model (T vs. G; OR=0.75, P<0.05) for both Asian and Caucasian children.
- Significant differences were observed in dominant, homozygous, and heterozygous models; a recessive model showed significance in Caucasians but not Asians.
Conclusions:
- The IKZF1 rs4132601 polymorphism shows a strong correlation with childhood ALL.
- T alleles, as well as TT, TT+TG, and TG genotypes, are associated with a decreased risk of childhood ALL.
Background:
Many studies have shown that IKAROS family zinc finger 1 (IKZF1) rs4132601 polymorphism is strongly linked to acute lymphoblastic leukemia (ALL) in children, but their conclusions have been inconsistent.
Objective:
This meta-analysis is set out to investigate the association between IKZF1 rs4132601 polymorphism and its susceptibility to childhood ALL.
Data And Methods:
On the basis of inclusion criteria, PubMed, EMBASE, Web of Science, CNKI, China Wanfang, VIP, and other databases were searched from the time of the establishment of the library database to December 2019 for all case-control studies. Stata 15.0 was applied for meta-analysis to calculate the combined odds ratio (OR) value and 95% confidence interval (CI) of each genotype at IKZF1 rs4132601. Subgroup analysis done by ethnicity, sensitivity analysis, and publication bias assessment was further performed.
Results:
Nine pieces of literature was included in this meta-analysis, including 2281 children with ALL and 2923 controls. There were significant differences in the allelic model (T vs. G: combined OR=0.75, 95% CI: 0.68-0.82, P<0.05) in both Asian and Caucasian children. In addition to this, there were statistically significant differences in the dominant, homozygous and heterozygous genetic model in both Asian and Caucasian children. The difference was significant in the recessive genetic model (TT vs. TG+GG: combined OR=0.75, 95% CI: 0.67-0.84) in Caucasian children, but not in Asian children (combined OR=0.85, 95% CI: 0.70-1.04, P>0.05).
Conclusion:
There is a strong correlation between IKZF1 rs4132601 polymorphism and ALL in children. Compared with the G allele, T alleles can lower the risk of childhood ALL, and TT, TT+TG and TG genotypes can also reduce the risk of ALL in children.
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