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Updated: Nov 15, 2025
Radiotracer Administration for High Temporal Resolution Positron Emission Tomography of the Human Brain: Application to FDG-fPET
Published on: October 22, 2019
18F-Fluorothymidine PET for Functional Response Assessment Following Radiation Therapy for Extramedullary
Belinda A Campbell, Jason Callahan, Merrole Cole-Sinclair1
1Department of Haematology, St Vincent's Hospital Melbourne, Fitzroy, Victoria, Australia.
Abstract:
As a marker of cellular proliferation, 18F-fluorothymidine (FLT) PET can detect the distribution of proliferating hematopoiesis and has an emerging role in the investigation of hematopoietic disorders. These images demonstrate the novel utility of 18F-FLT PET for imaging sites of extramedullary hematopoiesis (EMH) in a patient with Chuvash-type polycythemia and suggest a role for 18F-FLT PET in response assessment following radiotherapy. Further, the discordant response observed in the irradiated marrow and sites of EMH is a unique discovery, possibly suggesting the influence of the microenvironment favoring more rapid recovery of proliferative function within EMH sites.
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