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LSD: permanent behavioral effect in rats.

P B Silverman¹

¹Department of Psychiatry and Behavioral Sciences, University of Texas Medical School, Houston 77030.

European Journal of Pharmacology

|March 1, 1988

Summary

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Rats treated with lysergic acid diethylamide (LSD) showed circling behavior, which later occurred even without the drug when re-exposed to the environment. This suggests a learned response to LSD exposure.

Area of Science:

Neuroscience
Pharmacology
Behavioral Science

Background:

Unilateral nigrostriatal lesions in rats using 6-hydroxydopamine (6-OHDA) create an animal model for studying motor control.
Previous research indicated apomorphine can induce rotational behavior in lesioned rats.

Purpose of the Study:

To investigate the effects of lysergic acid diethylamide (LSD) on motor behavior in rats with unilateral nigrostriatal lesions.
To determine if environmental cues associated with LSD administration can elicit a conditioned motor response.

Main Methods:

Induction of unilateral nigrostriatal lesions in rats using 6-hydroxydopamine (6-OHDA).
Administration of systemic lysergic acid diethylamide (LSD) and observation of acute contralateral rotation.
Re-introduction of animals to the drug-associated environment after a delay to assess latent behavioral responses.

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Main Results:

Systemic LSD administration induced acute contralateral rotation in lesioned rats, similar to apomorphine effects.
A latent, undrugged contralateral rotation behavior emerged after repeated LSD exposure or even a single treatment.
This learned rotation persisted for weeks and was triggered by re-exposure to the environment where LSD was previously administered.

Conclusions:

Lysergic acid diethylamide (LSD) can induce both acute motor effects and a long-lasting, environmentally conditioned motor response in rats with nigrostriatal damage.
The findings suggest that environmental cues associated with drug administration can elicit complex, learned behaviors, highlighting the interplay between pharmacology and environmental conditioning in neurological models.