Related Experiment Video
Updated: Nov 15, 2025

Large-Scale SARS-CoV-2 Testing Utilizing Saliva and Transposition Sample Pooling
Published on: June 23, 2022
Group testing as a strategy for COVID-19 epidemiological monitoring and community surveillance
Vincent Brault1, Bastien Mallein2, Jean-François Rupprecht3
1Université Grenoble Alpes, CNRS, Grenoble INP, LJK, Grenoble, France.
Abstract:
We propose an analysis and applications of sample pooling to the epidemiologic monitoring of COVID-19. We first introduce a model of the RT-qPCR process used to test for the presence of virus in a sample and construct a statistical model for the viral load in a typical infected individual inspired by large-scale clinical datasets. We present an application of group testing for the prevention of epidemic outbreak in closed connected communities. We then propose a method for the measure of the prevalence in a population taking into account the increased number of false negatives associated with the group testing method.
Related Concept Videos
Principles of Disease Surveillance
Steps in Outbreak Investigation
Statistical Methods for Analyzing Epidemiological Data
Sampling Plans
Random sampling is a method where each member of the population has an equal chance of being selected for the sample. It involves selecting individuals randomly, often using random number generators or lottery-type methods. For example, when analyzing the properties of a...
Study Designs in Epidemiology
Observational studies are those where the researcher does not intervene but rather observes natural variations. They include cross-sectional, cohort, and...
Introduction to Epidemiology

