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High quantities: Evaluating the association between cannabis use and propofol anesthesia during endoscopy
Ngozi Imasogie1, Rhiannon V Rose2, Aze Wilson3,4
1Department of Anesthesia, Yorkton Regional Centre, Yorkton, SK, Canada.
Plos One
|March 4, 2021
Summary
Cannabis use significantly increases the propofol dose required for adequate sedation during endoscopy procedures. This finding highlights a potential drug-drug interaction relevant to patient safety during sedation.
Area of Science:
- Anesthesiology
- Pharmacology
- Gastroenterology
Background:
- Endoscopy is a common procedure requiring sedation.
- Cannabis use is prevalent among patients undergoing medical procedures.
- Understanding cannabis's effect on sedation is crucial for patient safety.
Purpose of the Study:
- To evaluate the association between cannabis exposure and the propofol dose needed for adequate sedation during endoscopy.
- To determine if cannabis use impacts sedation requirements in patients undergoing endoscopic procedures.
Main Methods:
- A case-control study was conducted with 318 participants undergoing endoscopy.
- Cases reported cannabis exposure; controls did not.
- Propofol dosage, demographics, and procedure details were collected and analyzed.
Main Results:
- Cannabis exposure was associated with a significant increase in propofol dose (0.33 mg/kg/min vs. 0.18 mg/kg/min, p<0.0001).
- Cannabis use independently predicted higher propofol requirements.
- Daily cannabis users needed more propofol than weekly or monthly users.
Conclusions:
- Cannabis use is significantly associated with increased propofol requirements for endoscopy sedation.
- Further research is needed to elucidate the molecular mechanisms of this drug-drug interaction.
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