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Cyclic Anhydrides as Powerful Tools for Bioconjugation and Smart Delivery
Maria Vittoria Spanedda1, Line Bourel-Bonnet1
1Laboratoire de Conception et Application de Molécules Bioactives, 3Bio team, ITI InnoVec, UMR 7199 - CNRS/Université de Strasbourg, Faculté de Pharmacie, 74 route du Rhin, BP 60024, 67401 Illkirch Cedex, France.
Abstract:
Cyclic anhydrides are potent tools for bioconjugation; therefore, they are broadly used in the functionalization of biomolecules and carriers. The pH-dependent stability and reactivity, as well as the physical properties, can be tuned by the structure of the cyclic anhydride used; thus, their application in smart delivery systems has become very important. This review intends to cover the last updates in the use of cyclic anhydrides as pH-sensitive linkers, their differences in reactivity, and the latest applications found in bioconjugation chemistry or chemical biology, and when possible, in drug delivery.
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