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Avoiding Adverse Drug Withdrawal Events When Stopping Unnecessary Medications According to the STOPPFrail Criteria
Joseph T Hanlon1, Jennifer Tjia2
11University of Pittsburgh, Department of Medicine, Pittsburgh, Pennsylvania.
Objective:
To provide clinicians with information about avoiding adverse drug withdrawal events (ADWEs) when discontinuing unnecessary medications as per the STOPPFrail criteria.
Data Sources:
Searches of MEDLINE (1970-June 2020), the Cochrane Database of Systematic Reviews (through June 2020), Google Scholar (through June 2020).
Study Selection:
Reviews and original studies of ADWEs.
Data Extraction:
Tapering protocols for specific drugs/ classes from randomized controlled deprescribing trials.
Data Synthesis:
Six drug classes were identified as being high risk for physiological ADWEs.
Conclusion:
The occurrence of ADWEs is rare in comparison to adverse drug reactions in older adults. Few drugs/classes have been reported to have physiological ADWEs with abrupt discontinuation. For these we provide information about tapering protocols and symptom monitoring to avoid ADWEs.
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