Translating cell and gene therapies from concept to commercialisation. A commentary on a historical, ongoing journey

This commentary will summarise opinions on the progression of the next pillar of patient treatment; cell and gene therapy. The development of exemplar products will be discussed along with their respective journeys. This will be in comparison to present-day developments and the direction in which the field is heading with respect to future products. Important topics for consideration will be the use of various technologies, automation, scalability and the key considerations for those already involved, or those striving to enter the field. Discussions will consider the current Chemistry, manufacturing and control (CMC) procedures and where these will require consideration for improvement as we proceed into the future.