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The roles of STAT6 in regulating B cell fate, activation, and function
Wei Wang1, Luman Wang2, Bingbing Zha1
1Department of Endocrinology and Metabolism, Shanghai Fifth People's Hospital, Fudan University, Shanghai, 200240, China.
Abstract:
Signal transducers and activators of transcription (STATs) family of proteins are the key signal molecules in the JAK-STAT classical activation pathway of cell biology. STAT6, as a member of the STATs family, is principally activated by IL-4 and IL-13. In addition to Th2 cell differentiation, it plays a crucial role in promoting the development, differentiation, and class switching of B cells. STAT6 deficiency leads to impaired immune function, decreased glycolysis, and morphological changes in B cells, which will help develop various diseases. In this review, we will systematically summarize the major findings of how STAT6 regulates B cells to reveal the potential of STAT6 in treating human diseases.
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