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Src homolog and collagen homolog1 isoforms in acute and chronic liver injuries

Heming Ma1, Chang Wang1, Xu Liu1

  • 1Department of Hepatology, The First Hospital of Jilin University, Changchun, Jilin 130021, China.

Life Sciences
|March 4, 2021
PubMed

Insights

SHC1 proteins are crucial in liver health, regulating cell processes and impacting liver injury, fibrosis, and cancer. This review explores SHC1

Area of Science:

  • Molecular biology
  • Cell signaling
  • Hepatology

Background:

  • SHC proteins act as adaptors in cell surface receptor signaling.
  • SHC1 influences cell proliferation, apoptosis, reactive oxygen species (ROS), and oxidative stress.
  • Three SHC1 isoforms (p46shc, p52shc, p66shc) are expressed in hepatic cells.

Purpose of the Study:

  • To review the role of SHC1 in liver disease pathogenesis.
  • To explore SHC1's involvement in liver injury, fibrosis, and hepatocellular carcinoma (HCC).
  • To provide a foundation for future research on SHC1 in liver diseases.

Main Methods:

  • Literature review of recent studies on SHC1 and liver diseases.
  • Analysis of SHC1's regulatory functions in hepatic cells.
  • Synthesis of evidence linking SHC1 to liver injury and cancer progression.

Main Results:

  • SHC1 is implicated in acute and chronic liver injuries.
  • SHC1 plays a significant role in liver fibrosis development.
  • SHC1 is associated with the progression of hepatocellular carcinoma (HCC).

Conclusions:

  • SHC1 is a key player in the development and progression of various liver diseases.
  • Understanding SHC1's function is vital for therapeutic strategies against liver conditions.
  • Further research into SHC1 mechanisms can inform future liver disease treatments.
Keywords:
Acute liver injuryChronic liver injurySHC1p46shcp52shcp66shc

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