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COVID-19 fatality rates in hospitalized patients: systematic review and meta-analysis

Ana Macedo1, Nilza Gonçalves2, Cláudia Febra3

  • 1Keypoint - Consultoria Científica, Lda, Lisbon, Portugal; Departamento de Ciências Biomédicas e Medicina, Universidade do Algarve, Faro, Portugal.

Annals of Epidemiology
|March 4, 2021
PubMed

Insights

This study evaluated coronavirus disease (COVID-19) mortality rates, finding an overall 17.1% fatality. Critical care patients faced a significantly higher mortality rate of 40.5%.

Area of Science:

  • Epidemiology
  • Infectious Diseases
  • Public Health

Background:

  • Coronavirus disease (COVID-19) is a novel infectious disease.
  • Accurate mortality rates for COVID-19 were largely unknown.
  • This study aimed to determine COVID-19 case fatality rates.

Purpose of the Study:

  • To evaluate the mortality of COVID-19 patients.
  • To provide data for resource allocation and economic impact assessments.

Main Methods:

  • Systematic literature search of PubMed and EMBASE databases.
  • Inclusion of studies on clinical characteristics and outcomes of COVID-19 patients.
  • Independent article selection by two authors.

Main Results:

  • A total of 33 studies comprising 13,398 COVID-19 patients were analyzed.
  • The overall COVID-19 mortality rate was 17.1%.
  • Mortality rates were 11.5% for general hospital admissions and 40.5% for critical care cases.

Conclusions:

  • High mortality rates in COVID-19 patients necessitate careful resource allocation.
  • Understanding COVID-19 fatality is crucial for economic burden calculations during pandemics.
Abstract

Keywords:
COVID-19FatalityMortalitySARS-CoV-2coronavirusoutbreak

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