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Flavonoids against the SARS-CoV-2 induced inflammatory storm
Alena Liskova1, Marek Samec1, Lenka Koklesova1
1Clinic of Obstetrics and Gynecology, Jessenius Faculty of Medicine, Comenius University in Bratislava, 036 01 Martin, Slovakia.
Summary
Flavonoids, plant compounds, may help manage COVID-19 by reducing the dangerous cytokine storm. Their anti-inflammatory effects show promise for regulating immune responses in SARS-CoV-2 infection.
Area of Science:
- Biochemistry
- Immunology
- Pharmacology
Background:
- COVID-19 severity is linked to hypercytokinemia, or cytokine storm.
- Flavonoids are plant compounds known for their anti-inflammatory and cytokine-modulatory effects.
Purpose of the Study:
- To review the potential of flavonoids in modulating signaling pathways relevant to COVID-19.
- To explore how flavonoids can regulate inflammation and immunity during SARS-CoV-2 infection.
Main Methods:
- Literature review of existing studies on flavonoids and their effects on inflammatory pathways.
- Analysis of bioinformatics and molecular docking studies related to flavonoids and SARS-CoV-2.
Main Results:
- Flavonoids may regulate inflammatory mediators, inhibit endothelial activation, NLRP3 inflammasome, TLRs, and BRD4.
- Flavonoids can activate Nrf2, inhibit DPP4 and 3CLpro, and influence gut microbiota and ACE-2.
- Evidence suggests flavonoids positively impact COVID-19-related inflammation.
Conclusions:
- Flavonoids demonstrate broad biological activities beneficial for managing COVID-19.
- Their immunomodulatory and anti-inflammatory properties offer a promising therapeutic strategy against SARS-CoV-2.
- Further clinical investigation is warranted to confirm the efficacy of flavonoids in COVID-19 management.
Keywords:
Anti-inflammatory effectsCOVID-19Cytokine stormFlavonoidsImmunomodulationInflammationPhytochemicalsSARS-CoV-2More Related Videos
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