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Related Concept Videos

Conjugated Proteins02:50

Conjugated Proteins

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Simple proteins and protein complexes contain only amino acids. In contrast, many other proteins, called conjugated proteins, covalently bond with non-protein moieties.
Nucleoproteins are protein complexes that contain nucleic acids, categorized as deoxyribonucleoproteins (DNPs) or ribonucleoproteins (RNPs) respectively. The nucleosome is a typical example of a DNP where nuclear DNA is associated with histone proteins. The major antigen for the Covid-19 virus SARS-CoV is an RNP that is critical...
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Cancer Vaccines01:30

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Cancer treatment vaccines are a rapidly evolving field that offers a promising approach to immunotherapy. Unlike traditional vaccines that prevent diseases, cancer treatment vaccines are designed to treat existing cancers by stimulating the immune system to recognize and attack cancer cells.
Cancer vaccines come in two categories: preventive (prophylactic) and treatment (active). Preventive vaccines, such as the Human Papillomavirus (HPV) vaccine, protect against viruses that cause certain...
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Related Experiment Video

Updated: Nov 15, 2025

Protocol for Recombinant RBD-based SARS Vaccines: Protein Preparation, Animal Vaccination and Neutralization Detection
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Development of SARS-CoV-2 vaccines.

Leticia A Barajas-Nava1

  • 1Unidad de Investigación de Medicina Basada en Evidencias, Hospital Infantil de México Federico Gómez, Mexico City, Mexico.

Boletin Medico Del Hospital Infantil De Mexico
|March 4, 2021
PubMed
Summary

This review identified 141 COVID-19 vaccines in development, using various technologies. While some show promise, continued research and global cooperation are crucial for effective SARS-CoV-2 vaccine development.

Keywords:
BiotechnologyBiotecnologíaCOVID-19Coronavirus disease 2019InfecciónInfectionPrevenciónPreventionSARS-CoV-2Severe acute respiratory syndrome coronavirus 2VaccineVacuna

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Area of Science:

  • Vaccinology
  • Infectious Diseases
  • Public Health

Background:

  • The COVID-19 pandemic presents global health challenges due to ongoing SARS-CoV-2 transmission.
  • Insufficient infection control and a lack of vaccines contribute to the pandemic's persistence.

Purpose of the Study:

  • To identify and describe potential vaccines for preventing COVID-19.
  • To review the landscape of SARS-CoV-2 vaccine development.

Main Methods:

  • Systematic literature review of scientific databases.
  • Searches extended to international organizations, health institutes, and reference lists.
  • Exclusion of studies on infection mechanisms, immunopathology, and genomics.

Main Results:

  • 141 SARS-CoV-2 vaccines were identified, utilizing technologies like inactivated/weakened viruses, viral vectors, nucleic acids, and proteins.
  • 13 vaccines (9.2%) are in clinical evaluation, with AZD1222 in Phase II-III.
  • Ad5-nCoV and mRNA-1273 vaccines demonstrated safety and induced neutralizing antibodies.

Conclusions:

  • Despite significant development efforts, further research is essential for effective SARS-CoV-2 vaccines.
  • Collaborative efforts among vaccine developers, international health organizations, and policymakers are vital.
  • Addressing challenges is necessary to ensure the successful development of a viable COVID-19 vaccine.