Clonazepam-induced lichenoid drug eruption: a case report

Area of Science:

• Dermatology
• Pharmacology

Background:

• Lichenoid drug eruptions (LDE) are uncommon dermatoses that can mimic other skin conditions.
• Clonazepam, a medication for anxiety and seizures, is rarely associated with cutaneous adverse effects.

Observation:

• An 81-year-old male with Alzheimer's disease developed a violaceous, scaly rash on his lower extremities after starting clonazepam.
• The patient's skin eruption extended from his buttocks to his feet.

Findings:

• The lichenoid eruption resolved two months after discontinuing clonazepam.
• Corticosteroid therapy was initiated concurrently with drug cessation, aiding in the resolution of the rash.

Implications:

• This case underscores that clonazepam can induce lichenoid drug eruptions, though rare.
• Lichenoid drug eruptions are unlikely to resolve spontaneously and necessitate the withdrawal of the offending medication.