Tale of compounding oddities
Umang Agrawal1, Krutarth Kanjiya2, Camilla Rodrigues3
1Department of Infectious Diseases, PD Hinduja National Hospital and Medical Research Centre, Mumbai, Maharashtra, India drumangagrawal87@gmail.com.
A rare mutation detected by pyrosequencing in tuberculosis (TB) caused discordance with phenotypic drug susceptibility testing, highlighting challenges in diagnosing rifampicin resistance in TB.
Area of Science:
- Microbiology
- Genetics
- Clinical Medicine
Background:
- Tuberculosis (TB) diagnosis relies on identifying Mycobacterium tuberculosis (MTB).
- Rifampicin resistance is a critical factor in TB treatment, necessitating accurate drug susceptibility testing (DST).
- Discordance between genotypic and phenotypic DST can complicate treatment decisions.
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