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Related Experiment Video

Updated: Nov 15, 2025

Modeling Colitis-Associated Cancer with Azoxymethane AOM and Dextran Sulfate Sodium DSS
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A Functional Food Inhibits Azoxymethane/Dextran Sulfate Sodium-Induced Inflammatory Colorectal Cancer in Mice.

Jie Zhang1, Zhewen Chen2, Yanwen Lu1

  • 1Department of Endocrinology, The Affiliated Huai'an Hospital of Xuzhou Medical University, Huai'an, 223002, Jiangsu, People's Republic of China.

Oncotargets and Therapy
|March 5, 2021
PubMed
Summary

This functional food inhibited colorectal cancer growth in mice by improving gut health and immune response. It positively altered gut microbiota and metabolites, suggesting a novel therapeutic approach.

Keywords:
cancer nutritioncolorectal cancerfunctional foodgut microbiotametabolitetumor microenvironment

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Area of Science:

  • Oncology
  • Nutrition Science
  • Microbiome Research

Background:

  • Colorectal cancer (CRC) poses a significant global health challenge.
  • The gut microbiota and its metabolites play a crucial role in CRC development and progression.
  • Functional foods are increasingly explored for their potential health benefits, including cancer prevention and treatment.

Purpose of the Study:

  • To investigate the antitumor effects of a functional food containing 55 natural ingredients.
  • To elucidate the mechanisms by which this functional food impacts colorectal cancer growth.
  • To assess the functional food's influence on the gut microbiota, metabolites, and host immune response.

Main Methods:

  • A mouse model of colorectal cancer was established using azoxymethane/dextran sulfate sodium.
  • Serum cytokine levels, intestinal barrier function markers, and immune cell populations were analyzed.
  • 16S rRNA gene sequencing and liquid chromatography-mass spectrometry were employed to profile gut microbiota and fecal metabolites.

Main Results:

  • The functional food significantly reduced tumor growth and improved intestinal barrier function.
  • It modulated immune cell populations, increasing T cell proportions and interferon-γ production.
  • Significant alterations in gut microbiota composition (e.g., increased Bacteroides, Parasutterella) and fecal metabolites (e.g., increased acetic acid, ascorbic acid) were observed.

Conclusions:

  • The tested functional food demonstrates significant antitumor effects against colorectal cancer.
  • These effects are attributed to improved nutritional status, enhanced intestinal barrier function, and a modulated tumor microenvironment.
  • The functional food's impact on the gut microbiota and metabolites is a key mechanism underlying its anti-CRC activity.