A High-Yielding Synthesis of EIDD-2801 from Uridine
Alexander Steiner1,2, Desiree Znidar1,2, Sándor B Ötvös1,2
1Institute of Chemistry University of Graz, NAWI Graz Heinrichstrasse 28 8010 Graz Austria.
European Journal of Organic Chemistry
|March 5, 2021
Abstract:
A simple reordering of the reaction sequence allowed the improved synthesis of EIDD-2801, an antiviral drug with promising activity against the SARS-CoV-2 virus, starting from uridine. Compared to the original route, the yield was enhanced from 17 % to 61 %, and fewer isolation/purification steps were needed. In addition, a continuous flow procedure for the final acetonide deprotection was developed, which proved to be favorable toward selectivity and reproducibility.
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