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Ionic liquid-loaded microcapsules doped into dental resin infiltrants
Marla Cuppini1, Isadora Martini Garcia1, Virgínia Serra de Souza2
1Department of Dental Materials, School of Dentistry, Federal University of Rio Grande do Sul, Ramiro Barcelos Street, 2492, Rio Branco, 90035-003, Porto Alegre, RS, Brazil.
Bioactive Materials
|March 5, 2021
Summary
This study introduces novel resin infiltrants containing microcapsules loaded with ionic liquids (MC-IL) for dental applications. The new dental materials show promising physical properties and low cytotoxicity, enhancing restorative materials.
Area of Science:
- Dental Materials Science
- Biomaterials Engineering
- Nanotechnology in Dentistry
Background:
- Resin infiltrants manage early dental caries but use inert monomers.
- Novel formulations are needed to improve the efficacy of dental restorative materials.
Purpose of the Study:
- To develop and characterize a novel resin infiltrant incorporating microcapsules loaded with ionic liquid (MC-IL).
- To evaluate the physical properties and cytotoxicity of the developed dental resin infiltrant.
Main Methods:
- Synthesized ionic liquid (BMI.NTf2) and microcapsules (MC-IL).
- Analyzed MC-IL particle size, shape (SEM), and de-agglomeration.
- Formulated resin infiltrants with varying MC-IL concentrations (2.5%, 5%, 10% wt%).
- Evaluated ultimate tensile strength (UTS), contact angle, surface free energy (SFE), and cytotoxicity.
Main Results:
- MC-IL exhibited a mean particle size of 1.64 μm with nanoparticle characteristics.
- No significant difference in UTS was observed across groups.
- 10% MC-IL increased contact angle; 5% and 10% MC-IL reduced SFE.
- Human cell viability remained above 90% for all tested groups.
Conclusions:
- Microcapsule-based ionic liquid delivery systems are a promising strategy for enhancing dental restorative materials.
- The developed MC-IL resin infiltrants demonstrate favorable physical properties and biocompatibility.
- This approach offers potential for improved management of non-cavitated carious lesions.
