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Atherosclerosis is a progressive disorder characterized by the buildup of plaques on the arterial inner wall, causing them to narrow and harden over time. These plaques comprise lipids, calcium, blood components, carbohydrates, and fibrous tissue. The process primarily affects the intima of large and medium-sized arteries, reducing blood flow in any artery.Etiology and risk factorsThe cause of atherosclerosis is multifactorial, involving a complex interplay among endothelial injury, lipid...
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Coronary Artery Disease (CAD) originates from a series of events that impair the function of coronary arteries, the blood vessels responsible for delivering oxygen-rich blood to the heart muscle. The pathophysiology of CAD is closely linked to atherosclerosis, a chronic inflammatory and lipid-driven condition affecting the vascular endothelium.1. Endothelial DamageThe process begins with damage to the vascular endothelium, which serves as a protective barrier between the blood and the vessel...
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Peripheral artery disease (PAD) predominantly results from atherosclerosis, which involves the accumulation of fatty deposits, or plaques, within the walls of arteries. This causes them to narrow and harden, significantly reducing blood flow. PAD predominantly affects the legs, particularly the arteries supplying the thighs and calves. In rare cases, it may involve other arteries, including those in the arms.Etiology of PAD:The principal cause of PAD is atherosclerosis, which results from fatty...
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Understanding serum lipids is crucial for maintaining cardiovascular health and preventing heart disease and stroke.
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Updated: Nov 15, 2025

Cell-free Biochemical Fluorometric Enzymatic Assay for High-throughput Measurement of Lipid Peroxidation in High Density Lipoprotein
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[Oxidized phospholipids and atherosclerosis].

Min Zhao1, Bo-Yan Liu1, Shu-Cun Qin2

  • 1Institute of Atherosclerosis, College of Basic Medical Sciences, and Taishan Institute for Hydrogen Biomedicine, Shandong First Medical University & Shandong Academy of Medical Sciences, Taian 271000, China.

Sheng Li Xue Bao : [Acta Physiologica Sinica]
|March 5, 2021
PubMed
Summary
This summary is machine-generated.

Oxidized phospholipids (OxPLs) are key players in atherosclerosis development. Targeting these oxidized lipids offers a promising strategy to inhibit the progression of this cardiovascular disease.

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Area of Science:

  • Biochemistry
  • Cardiovascular Biology
  • Oxidative Stress

Background:

  • Phospholipids are vital biomembrane and lipoprotein constituents.
  • Oxidation of phospholipids generates oxidized phospholipids (OxPLs), leading to diverse biological activities.
  • OxPLs accumulate during atherosclerosis pathogenesis and influence disease progression via various pathways.

Purpose of the Study:

  • To review the formation and biological activities of oxidized phospholipids (OxPLs).
  • To summarize the interactions of OxPLs with key cells and lipoproteins in atherosclerosis.
  • To discuss recent research on targeting OxPLs for atherosclerosis inhibition.

Main Methods:

  • Literature review of phospholipid oxidation and OxPLs.
  • Analysis of OxPL interactions with endothelial cells, monocytes/macrophages, smooth muscle cells, and platelets.
  • Review of therapeutic strategies targeting OxPLs in atherosclerosis.

Main Results:

  • Phospholipid oxidation yields heterogeneous OxPLs with significant biological impact.
  • OxPLs actively participate in the pathological processes of atherosclerosis.
  • Targeting OxPLs demonstrates potential for inhibiting atherosclerosis.

Conclusions:

  • Oxidized phospholipids (OxPLs) are central to atherosclerosis pathogenesis.
  • Understanding OxPLs' roles provides insights into disease mechanisms.
  • Targeting OxPLs represents a promising therapeutic avenue for atherosclerosis.