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Circulating levels of clusterin and complement factor H in patients with obstructive sleep apnea

Martina Meszaros1, Peter Horvath1, Adrian Kis1

  • 1Department of Pulmonology, Semmelweis University, Budapest, Hungary.

Biomarkers in Medicine
|March 5, 2021
PubMed

Insights

Obstructive sleep apnea (OSA) activates the complement system. Researchers found higher clusterin levels in OSA patients, suggesting it may protect against membrane attack complex (MAC) formation.

Area of Science:

  • Immunology
  • Sleep Medicine
  • Biochemistry

Background:

  • Obstructive sleep apnea (OSA) is linked to complement system activation.
  • Despite activation, membrane attack complex (MAC) levels remain unchanged in OSA, indicating regulatory mechanisms.
  • Complement factor H (CFH) and clusterin are key regulators of the complement system.

Purpose of the Study:

  • To investigate the levels of complement regulators CFH and clusterin in patients with OSA.
  • To explore the potential role of these regulators in the pathophysiology of OSA.

Main Methods:

  • Plasma samples from 86 OSA patients and 33 control subjects were analyzed.
  • Quantification of clusterin and CFH levels was performed using plasma assays.

Main Results:

  • No significant difference in CFH levels was observed between OSA patients and controls.
  • Clusterin levels were significantly higher in OSA patients compared to controls.
  • A trend towards a positive correlation between clusterin levels and OSA severity was noted.

Conclusions:

  • Elevated clusterin levels in OSA patients may play a protective role.
  • Increased clusterin might inhibit MAC formation, potentially mitigating complement-mediated damage in OSA.
  • Further research is warranted to elucidate the precise role of clusterin in OSA.

Keywords:
OSAcomplement systeminflammationsleep apnea

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