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Papillary squamous cell carcinoma in three young dogs
G K Ogilvie1, J P Sundberg, M K O'Banion
1Department of Veterinary Clinical Medicine, College of Veterinary Medicine, University of Illinois, Urbana 61801.
Journal of the American Veterinary Medical Association
|April 1, 1988
Summary
Papillary squamous cell carcinomas in dogs present aggressive oral tumors. While resembling papillomas, these cancers are not caused by viruses and require multimodal treatment including surgery and radiotherapy for successful management.
Area of Science:
- Veterinary Oncology
- Oral Pathology
- Canine Cancer Research
Background:
- Papillary squamous cell carcinomas (PSCs) are rare oral tumors in dogs.
- These tumors can exhibit aggressive local invasion and resemble viral papillomas superficially.
- The etiology of canine oral PSCs remains largely unknown.
Observation:
- Three young dogs presented with gingival papillary squamous cell carcinomas.
- Tumors demonstrated local invasion into soft tissues and bone in some cases.
- Initial surgical excision was insufficient for tumor eradication in two dogs.
Findings:
- Combined surgery and radiotherapy proved effective in managing the tumors.
- No recurrence was observed in dogs treated with surgery and radiotherapy for up to 39 months.
- Extensive testing, including immunohistochemistry and Southern blot hybridization, failed to detect papillomavirus in the tumor tissues, ruling out a viral etiology.
Implications:
- This study highlights the aggressive nature of canine oral PSCs and the limitations of solely surgical treatment.
- Multimodal therapy combining surgery and radiotherapy offers a promising treatment strategy with long-term remission potential.
- The findings underscore that canine oral PSCs are distinct from viral papillomas and suggest a non-viral oncogenic pathway.