Related Experiment Video

Updated: Nov 15, 2025

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques
06:29

Cardiac Magnetic Resonance for the Evaluation of Suspected Cardiac Thrombus: Conventional and Emerging Techniques

Published on: June 11, 2019

10.7K

Location of recurrent cardiovascular events and anticardiolipin antibodies

Javier Galán-González1, Sergio Rico-Martín2, Julián F Calderón-García2

  • 1Department of Internal Medicine, Hospital San Pedro Alcántara, Cáceres, Spain.

European Journal of Clinical Investigation
|March 5, 2021
PubMed

Insights

Anticardiolipin (aCL) antibodies increase the risk of distal artery ischemic events, such as stroke or leg events, but not coronary artery events in patients with symptomatic artery disease.

Area of Science:

  • Cardiovascular Medicine
  • Immunology
  • Vascular Biology

Background:

  • The link between anticardiolipin (aCL) antibodies and cardiovascular events is not fully understood and may differ based on arterial location.
  • Previous research has yielded uncertain findings regarding the association between aCL antibodies and ischemic events.

Purpose of the Study:

  • To investigate the relationship between anticardiolipin antibodies and the risk of subsequent ischemic events in different arterial locations.
  • To determine if aCL antibodies are an independent risk factor for specific types of cardiovascular events.

Main Methods:

  • The study utilized data from the FRENA registry, an ongoing registry of stable outpatients with symptomatic coronary artery disease (CAD), cerebrovascular disease (CVD), or peripheral artery disease (PAD).
  • Researchers cross-referenced the rate of subsequent ischemic events with the presence of aCL antibodies (any isotype, IgG, or IgM).
  • Multivariate Cox analysis was performed to adjust for relevant clinical covariates.

Main Results:

  • Out of 1387 recruited patients, 120 (8.7%) had positive aCL antibody levels.
  • Patients with positive aCL antibodies showed a higher risk of distal artery events (ischemic stroke or critical leg events) compared to those with undetectable or low levels (rate ratio: 1.66).
  • Multivariate analysis confirmed that aCL antibody positivity is an independent risk factor for distal events (hazard ratio: 1.60; P < .05), but no association with coronary events was found.

Conclusions:

  • Anticardiolipin antibody positivity is linked to an increased risk of subsequent ischemic events in distal arteries (cerebral or leg arteries).
  • The study found no association between aCL antibodies and coronary artery events.
  • Anticardiolipin antibodies appear to have a differential impact on the location of ischemic events in patients with symptomatic artery disease.
Abstract

Keywords:
IgGIgManticardiolipin antibodiesischaemic eventmyocardial infarctionsymptomatic artery disease

More Related Videos

Remote Magnetic Navigation for Accurate, Real-time Catheter Positioning and Ablation in Cardiac Electrophysiology Procedures09:13

Remote Magnetic Navigation for Accurate, Real-time Catheter Positioning and Ablation in Cardiac Electrophysiology Procedures

Published on: April 21, 2013

28.2K
Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation28:13

Catheter Ablation in Combination With Left Atrial Appendage Closure for Atrial Fibrillation

Published on: February 26, 2013

33.7K

Related Concept Videos

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies01:22

Rheumatic Heart Disease II: Clinical Manifestations and Diagnostic Studies

The key clinical manifestations of Rheumatic heart disease (RHD) include several distinct cardiac symptoms.Carditis, a hallmark of acute rheumatic fever, involves inflammation of the heart's endocardium, myocardium, and pericardium. Chronic RHD often results from recurrent episodes of carditis. Its symptoms include the following:Murmurs are caused by valvular damage, especially to the mitral and aortic valves. Mitral stenosis or regurgitation is common, with characteristic heart murmurs...
217
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
143
Pericarditis II: Clinical Features and Diagnostic Tests01:19

Pericarditis II: Clinical Features and Diagnostic Tests

Pericarditis is distinguished by inflammation of the pericardium, the fibrous sac that encases the heart. It can be acute, lasting less than six weeks, or chronic, persisting for over three months. Understanding its clinical manifestations and diagnostic findings is crucial for timely and effective management.Clinical ManifestationsWhile pericarditis can be asymptomatic, it usually presents with characteristic symptoms such as:Chest Pain: The most characteristic symptom of pericarditis is chest...
141
Acute Coronary Syndrome III: Diagnostic Studies01:30

Acute Coronary Syndrome III: Diagnostic Studies

Diagnosing acute coronary syndrome or ACS begins with a thorough patient history. Notable symptoms include central, crushing chest pain radiating to the left arm, neck, jaw, or back, along with shortness of breath, sweating (diaphoresis), nausea, vomiting, dizziness, and palpitations.It is crucial to note any history of cardiac illnesses and assess risk factors, including age, gender, smoking, hypertension, diabetes, hyperlipidemia, and a sedentary lifestyle.During physical examination, vital...
86
Atherosclerosis II: Clinical Manifestations and Diagnostic Tests01:27

Atherosclerosis II: Clinical Manifestations and Diagnostic Tests

Atherosclerosis is a progressive disorder that leads to the thickening and narrowing of arterial walls due to plaque buildup. This condition can cause various symptoms depending on the arteries affected:Coronary Artery Disease (CAD): This condition affects the coronary arteries and may lead to chest pain (angina), shortness of breath (dyspnea), heart attacks, and other heart disease symptoms.Cerebrovascular Disease: This affects blood flow to the brain, causing transient ischemic attacks (TIAs)...
151
Myocarditis II: Clinical Features and Diagnostic Tests01:27

Myocarditis II: Clinical Features and Diagnostic Tests

Myocarditis is an inflammation of the heart muscle. The symptoms vary widely, encompassing asymptomatic presentations to severe, acute manifestations.Clinical PresentationAsymptomatic cases: In some instances, myocarditis may be asymptomatic, with the infection resolving without intervention. These cases often go undetected unless discovered incidentally through diagnostic imaging or tests conducted for other reasons.General Early Symptoms: Early symptoms of myocarditis are non-specific and can...
96