Related Experiment Video

Updated: Nov 15, 2025

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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Molecular mechanism of liver X receptors in cancer therapeutics

Qiang Wang1, Jing Wang1, Jiayou Wang1

  • 1Institute of Life Sciences, Jiangsu University, Zhenjiang, Jiangsu, China.

Life Sciences
|March 5, 2021
PubMed

Insights

Liver X receptors (LXRs) are nuclear receptors regulating metabolism and immune function. Activating LXRs shows potential in cancer treatment by inhibiting tumor growth and promoting cancer cell death.

Area of Science:

  • Molecular Biology
  • Cell Biology
  • Endocrinology

Background:

  • Liver X receptors (LXRs) are part of the nuclear receptor superfamily.
  • Initially termed 'orphan receptors', LXRs are activated by oxysterols.
  • LXRs form heterodimers with Retinol X Receptors to regulate cellular processes.

Purpose of the Study:

  • To review recent advancements in understanding Liver X receptors (LXRs).
  • To explore the role of LXRs in cancer, including their structure, function, and signaling pathways.
  • To discuss the therapeutic potential of targeting LXRs in cancer treatment.

Main Methods:

  • Literature review of studies on LXRs.
  • Analysis of LXR structure, function, and signaling pathways.
  • Investigation of LXR activation mechanisms in cancer.

Main Results:

  • LXRs play a role in immune function and immune tolerance.
  • Activation of LXRs inhibits tumorigenesis and induces apoptosis in cancer cells.
  • LXRs represent promising therapeutic targets for cancer therapy.

Conclusions:

  • LXRs are crucial regulators of metabolism and immunity.
  • Targeting LXRs offers a potential strategy for cancer treatment.
  • Further research into LXR activation mechanisms can advance cancer therapy.
Keywords:
CancerCancer therapeuticsLiver X receptorsNuclear receptors

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